Vasopressin Resistant Diabetes Insipidus

It is feasible that the primary title of the report Nephrogenic Diabetic issues Insipidus is not the name you anticipated. Please check the words noting to discover the alternative name(s) as well as disorder class(s) covered by this report.


  • NDI
  • vasopressin-resistant diabetic issues insipidus
  • hereditary nephrogenic diabetic issues insipidus
  • congenital nephrogenic diabetic issues insipidus
  • gotten nephrogenic diabetes mellitus insipidus

Disorder Communities

  • None

General Conversation
Nephrogenic diabetes mellitus insipidus (NDI) is an unusual kidney problem that could be inherited or acquired. NDI is not connected to the a lot more usual diabetes mellitus (sugar diabetes), where the physical body does not generate or appropriately use insulin. NDI is a distinct problem caused by complete or partial resistance of the kidneys to arginine vasopressin (AVP). Vasopressin is an antidiuretic hormonal agent used by the kidney to handle water balance in the physical body. NDI triggers chronic excessive thirst (polydipsia), excessive pee production (polyuria), and potentially dehydration. If left unattended, repetitive episodes of serious dehydration may create, at some point resulting in serious difficulties. The majority of instances of genetic NDI are inherited as X-linked recessive problems. Unusual cases are inherited as an autosomal recessive or leading condition. Two different genetics have been recognized that trigger genetic NDI. NDI could also be gotten throughout life as an outcome of substance abuse (e.g., lithium treatment), kidney illness, blockage of the tubes that carry urine from the kidneys to the bladder (ureters), as well as prolonged metabolic inequalities such as low degrees of potassium in the blood (hypokalemia) or high levels of calcium in the blood (hypercalcemia). NDI may also be a short-term complication related to maternity.

The term nephrogenic diabetes insipidus wased initially used in the clinical literature in 1947. In the past, the term diabetic issues insipidus renalis was utilized to signify this condition. NDI is different from central diabetes insipidus, which is a rare problem characterized by the failure of the body to create vasopressin (rather than vasopressin resistance as in NDI).

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