Agnogenic Myeloid Metaplasia (AMM)

It is possible that the main title of the record Primary Myelofibrosis is not the name you anticipated. Kindly check the words listing to find the alternating name(s) and disorder subdivision(s) covered by this report.


  • IM
  • PMF
  • agnogenic myeloid metaplasia (AMM)
  • persistent idiopathic myelofibrosis (CIMF)
  • myelofibrosis with myeloid metaplasia
  • idiopathic myelofibrosis

Problem Neighborhoods

  • None

General Conversation
Main myelofibrosis is a rare bone marrow problem that is defined by problems in blood cell production (hematopoiesis) and scarring (development of coarse tissue) within the bone marrow. Bone marrow is the soft, squishy cells that loads the center of many bones. Bone marrow includes specialized cells called hematopoietic stem cells that grow and ultimately turn into among the 3 primary sorts of blood cells: red blood cells, leukocyte or platelets. In main myelofibrosis, a change in the DNA of a single hematopoietic stem cell causes the irregular cell to consistently recreate itself. Ultimately, these abnormal cells crowd out normal, healthy and balanced cells in the marrow as well as, in addition to scarring within the marrow, interrupt the manufacturing of red as well as white blood cells as well as platelets.

The signs connected with key myelofibrosis differ and also belong to the abnormalities impacting blood cell manufacturing. Influenced individuals could not have signs at the time of medical diagnosis (asymptomatic) may continue to be symptom-free for years. At some point, impacted individuals may establish tiredness, fever, frequent infections, pale skin, night sweats and also inexplicable weight management. An enlarged (spleen) is a typical finding. An enlarged liver (hepatomegaly) may also take place.

In roughly 50 percent of situations, a mutation of the JAK2 genetics has been found. The exact function this abnormal gene plays in the development of the problem is unidentified.

Primary myelofibrosis belongs to a team of illness known as the myeloproliferative tumors (MPNs). This group of disorders is defined by the overflow (expansion) of several of the 3 major blood cell lines – red or white blood cells or platelets. 3 other conditions are typically categorized as MPNs: chronic myeloid leukemia, vital thrombocythemia and also polycythemia vera. Myelofibrosis might take place as a secondary feature of polycythemia vera or essential thrombocytyemia. Considering that the MPNs are defined by unrestrained cell growth, they might also be categorized as blood cancers cells.

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